Superdrol
Methasterone
Design steroid methasterone; notorious for severe hepatotoxicity. Simple model — peak calibrated.
Key takeaways
- Former OTC "prohormone" sold from 2005; now a Schedule III controlled substance.
- 17-alpha-alkylated oral with a ~10-hour half-life — twice-daily dosing is standard.
- Severe hepatotoxicity: case reports of cholestatic jaundice even on short, modest-dose courses.
- No formal human PK studies exist — the plotted curve is a calibrated estimate.
Overview
What it is
Superdrol (methasterone) is a synthetic oral anabolic steroid sold over the counter as a "prohormone" from 2005 until the FDA forced its removal and it became a controlled substance. It is a 17-alpha-alkylated DHT derivative with two methyl groups that resist hepatic breakdown and deliver high oral activity.
Pharmacokinetics
The half-life is about 10 hours with roughly 50% oral bioavailability, so community protocols split the daily dose in two. Formal human PK studies do not exist, so the curve values are calibrated estimates rather than measured data.
Harm reduction
The defining issue is severe hepatotoxicity: published case reports document cholestatic jaundice and acute liver injury, sometimes after short courses at modest doses. Lipid disruption and blood-pressure elevation are also pronounced. It does not aromatize, so estrogenic effects are absent — the risk is hepatic and cardiovascular.
Reported dosing protocols
Protocols reported in research literature and clinic/community use — informational context, not a dosing recommendation.
| Use case | Dose | Route | Frequency | Duration |
|---|---|---|---|---|
| Performance (community) | 10–20 mg daily | Oral | Split 2× daily | 3–4 weeks |
Pharmacokinetic summary
- Model tier
- Simple (t½ + F, Tmax estimated)
- Half-life
- 10.0 hours
- Cmax
- 119.8 ng/dL
- Bioavailability
- 50%
- Typical dose
- 10–30 mg
Harm reduction
- Aromatizes
- No
- DHT derivative
- Yes
- Hepatotoxicity
- severe
- Injection frequency
- Oral, 2×/day
Frequently asked questions
Is Superdrol legal?
No. Methasterone was sold as a supplement from 2005 until the FDA moved against it, and the 2014 Designer Anabolic Steroid Control Act made it a Schedule III controlled substance in the US. Anything sold today is unregulated underground product.
How harsh is Superdrol on the liver?
Among the harshest orals documented. Peer-reviewed case series describe cholestatic jaundice and acute liver injury, including cases after 2–3 weeks at 10–30 mg daily, and HDL suppression is severe. Liver enzymes can stay abnormal for months afterward.
Does Superdrol cause estrogenic side effects?
No. As a DHT derivative it does not aromatize, so water retention and gynecomastia are not direct concerns. The flip side is losing estrogen's joint and lipid cushioning while taking on severe hepatic strain.
References
- Wikipedia (Methasterone) — Cmax calibrated to ng/dL serum peak.
- Shah et al., Clin Gastroenterol Hepatol 2008 — methasterone liver injury case series — Five cases of cholestatic liver injury after OTC methasterone use.
- Wikipedia — Methasterone — Regulatory history and general reference.
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