Nandrolone Phenylpropionate
NPP · Durabolin
Short-acting 19-nor (NPP); faster clearance than Deca. Good for frontloading.
Key takeaways
- Short-acting nandrolone ester (NPP, Durabolin); same hormone as Deca, much faster clearance.
- ~2.4-day half-life; every-other-day to 3× weekly injection.
- Aromatizes weakly (~20% of testosterone) but is progestogenic; gynecomastia risk persists.
- Not hepatotoxic; suppression and 19-norandrosterone detection both run long.
Reported dosing protocols
Protocols reported in research literature and clinic/community use — informational context, not a dosing recommendation.
| Use case | Dose | Route | Frequency | Duration |
|---|---|---|---|---|
| Anemia / wasting (historical label) | 25–50 mg | IM | Weekly | Weeks–months |
| Performance (community) | 100–200 mg weekly | IM | EOD–3× weekly (split) | 6–10 weeks |
Pharmacokinetic summary
- Model tier
- Advanced (t½ + Cmax + Tmax + F)
- Half-life
- 2.4 days
- Cmax
- 700 ng/dL
- Tmax
- 1.0 days
- Bioavailability
- 67%
- Typical dose
- 50–200 mg
Harm reduction
- Aromatizes
- Yes
- DHT derivative
- No
- Injection frequency
- EOD–3×/week
Frequently asked questions
NPP vs Deca — why pick one?
Same hormone, different ester. NPP's ~2.4-day half-life reaches steady state in about two weeks and clears in days if side effects appear; the decanoate depot takes months to fully clear. NPP costs more frequent injections for that control.
Does nandrolone really help joints?
Reported widely, proven weakly. Nandrolone raises collagen synthesis markers in some studies, but controlled human evidence for joint relief is thin, and any comfort effect may partly be water retention. It shouldn't be treated as a joint therapy.
How long is NPP detectable?
Longer than the ester suggests. Labs screen for 19-norandrosterone by GC-MS/MS with IRMS confirmation. This entry estimates a 60–120 day window, extrapolated from decanoate data adjusted for the shorter depot.
References
- PubMed / Nandrolone ester PK
- Minto et al., J Pharmacol Exp Ther 1997 — nandrolone ester PK — Human PK/PD comparison of nandrolone esters including phenylpropionate; the ester PK data behind this entry.
Related compounds
Nandrolone Decanoate
Long-acting 19-nor (Deca-Durabolin); collagen/joint benefits, very long clearance.
Testosterone Enanthate
Long-acting testosterone ester; the most common TRT and cycle base. Reaches steady state in ~5 weeks.
Testosterone Cypionate
Standard US TRT ester with a slightly longer release tail than enanthate. Steady state ~4–5 weeks.
Protocols featuring Nandrolone Phenylpropionate
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