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Harm-reduction information only — not medical advice. In crisis or experiencing adverse effects, contact a healthcare professional or your local emergency services immediately.

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Peptides MetabolicWeight Loss

MOTS-c

Mitochondrial-derived peptide

Mitochondrial-derived peptide that regulates metabolic homeostasis and AMPK signaling.

🚧 Expanded guide coming soon. This compound has PK data and a source — a full overview, mechanism, and dosing guide is pending editorial review.

Pharmacokinetic summary

Model tier
Simple (t½ + F, Tmax estimated)
Half-life
0.5 days
Bioavailability
50%
Typical dose
2.5–10 mg

Related compounds

SS-31 (Elamipretide)

Mitochondria-targeted peptide that stabilizes cardiolipin; researched for metabolic and renal disease.

Semaglutide Injection (Ozempic/Wegovy)

Long-acting GLP-1 receptor agonist for type 2 diabetes and weight loss; weekly injection.

Semaglutide Oral (Rybelsus)

Oral semaglutide with very low bioavailability; taken fasting.

Protocols featuring MOTS-c

Mito Stack

Sequenced mitochondrial protocol: SS-31 (elamipretide) 4mg daily for the first 6 weeks, then MOTS-c 5mg 3×/week for the following 8 weeks. Modeled on the documented SS-31/MOTS-c cycling protocol.

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