Harm-reduction information only — not medical advice. In crisis or experiencing adverse effects, contact a healthcare professional or your local emergency services immediately.

Semaglutide Titration (20 weeks)

FDA Wegovy label titration: 0.25 → 0.5 → 1.0 → 1.7 → 2.4 mg weekly, escalating every 4 weeks to the 2.4mg maintenance dose.

Concentration over time

Reference ranges

Concentration values over time. Rows are sampled dates; columns are compounds.
Date	Semaglutide Injection (Ozempic/Wegovy)
W1	0.00
W2	1534.89
W4	2407.65
W6	2318.63
W7	3738.00
W9	7672.34
W11	5462.51
W12	7713.84
W14	15587.04
W16	10019.31
W17	16240.32
W19	23547.03
W21	14589.37

Protocol summary

Semaglutide Titration (20 weeks) · 20 weeks starting Jul 20, 26

Semaglutide Injection (Ozempic/Wegovy) — 250 mcg Every 7 days, weeks 0–3
Semaglutide Injection (Ozempic/Wegovy) — 500 mcg Every 7 days, weeks 4–7
Semaglutide Injection (Ozempic/Wegovy) — 1.00 mg Every 7 days, weeks 8–11
Semaglutide Injection (Ozempic/Wegovy) — 1.70 mg Every 7 days, weeks 12–15
Semaglutide Injection (Ozempic/Wegovy) — 2.40 mg Every 7 days, weeks 16–20

Protocol nameAuthorStart dateCycle length (weeks)Shared URL always reflects recipient's "today"

Compounds

Dose (mg)ScheduleOffset (days)From weekThrough weekAdjust levels (0%)

Accumulate

Typical 250 mcg–2.40 mg · Every 7 days

Dose (mg)ScheduleOffset (days)From weekThrough weekAdjust levels (0%)

Accumulate

Typical 250 mcg–2.40 mg · Every 7 days

Dose (mg)ScheduleOffset (days)From weekThrough weekAdjust levels (0%)

Accumulate

Typical 250 mcg–2.40 mg · Every 7 days

Dose (mg)ScheduleOffset (days)From weekThrough weekAdjust levels (0%)

Accumulate

Typical 250 mcg–2.40 mg · Every 7 days

Dose (mg)ScheduleOffset (days)From weekThrough weekAdjust levels (0%)

Accumulate

Typical 250 mcg–2.40 mg · Every 7 days

Protocol overview

Category: weightloss
Duration: 20 weeks
Compounds: 5
Tags: glp-1, weightloss, semaglutide, titration

Compounds in this protocol

Semaglutide 0.25mg — 0.25 mg, every-7-days (weeks 0-3)
Semaglutide 0.5mg — 0.5 mg, every-7-days (weeks 4-7)
Semaglutide 1.0mg — 1 mg, every-7-days (weeks 8-11)
Semaglutide 1.7mg — 1.7 mg, every-7-days (weeks 12-15)
Semaglutide 2.4mg — 2.4 mg, every-7-days (weeks 16-20)

How to read this protocol

The chart above shows the modeled blood concentration of each compound over the 20-week duration. Each compound accumulates toward steady state (roughly 5 half-lives). The peak-to-trough ratio within each dose interval depends on the injection frequency relative to the half-life.

Use the [peak-trough estimator](/tools/peak-trough) to see predicted levels at any point, or the [clearance calculator](/tools/clearance) to estimate washout after the protocol ends. The [PCT planner](/pct-planner) estimates when to start post-cycle therapy.

Educational only. Not medical advice. Concentration values are modeled estimates based on population pharmacokinetics, not predictions of individual blood levels.