CagriSema Titration (Cagrilintide + Semaglutide)
Investigational CagriSema combination (REDEFINE trial) — 16-week parallel titration of cagrilintide + semaglutide dosed weekly to the 2.4/2.4mg maintenance target.
Concentration over time
| Date | Semaglutide Injection (Ozempic/Wegovy) | Cagrilintide |
|---|---|---|
| W1 | 0.00 | 0.00 |
| W2 | 1534.89 | 0.14 |
| W4 | 2407.65 | 0.17 |
| W6 | 2318.63 | 0.30 |
| W7 | 3738.00 | 0.33 |
| W9 | 7672.34 | 0.59 |
| W11 | 5462.51 | 0.65 |
| W12 | 7713.84 | 1.18 |
| W14 | 15587.04 | 1.30 |
| W16 | 10019.31 | 2.37 |
| W17 | 16240.32 | 2.61 |
| W19 | 23547.03 | |
| W21 | 14589.37 |
Protocol summary
CagriSema Titration (Cagrilintide + Semaglutide) · 20 weeks starting Jul 20, 26
- Semaglutide Injection (Ozempic/Wegovy) — 250 mcg Every 7 days, weeks 0–3
- Cagrilintide — 160 mcg Every 7 days, weeks 0–3
- Semaglutide Injection (Ozempic/Wegovy) — 500 mcg Every 7 days, weeks 4–7
- Cagrilintide — 300 mcg Every 7 days, weeks 4–7
- Semaglutide Injection (Ozempic/Wegovy) — 1.00 mg Every 7 days, weeks 8–11
- Cagrilintide — 600 mcg Every 7 days, weeks 8–11
- Semaglutide Injection (Ozempic/Wegovy) — 1.70 mg Every 7 days, weeks 12–15
- Cagrilintide — 1.20 mg Every 7 days, weeks 12–15
- Semaglutide Injection (Ozempic/Wegovy) — 2.40 mg Every 7 days, weeks 16–20
- Cagrilintide — 2.40 mg Every 7 days, weeks 16–20
Protocol overview
- Category
- weightloss
- Duration
- 20 weeks
- Compounds
- 10
- Tags
- glp-1, amylin, weightloss, cagrisema, blend, titration
Compounds in this protocol
- Semaglutide 0.25mg — 0.25 mg, every-7-days (weeks 0-3)
- Cagrilintide 0.16mg — 0.16 mg, every-7-days (weeks 0-3)
- Semaglutide 0.5mg — 0.5 mg, every-7-days (weeks 4-7)
- Cagrilintide 0.3mg — 0.3 mg, every-7-days (weeks 4-7)
- Semaglutide 1.0mg — 1 mg, every-7-days (weeks 8-11)
- Cagrilintide 0.6mg — 0.6 mg, every-7-days (weeks 8-11)
- Semaglutide 1.7mg — 1.7 mg, every-7-days (weeks 12-15)
- Cagrilintide 1.2mg — 1.2 mg, every-7-days (weeks 12-15)
- Semaglutide 2.4mg — 2.4 mg, every-7-days (weeks 16-20)
- Cagrilintide 2.4mg — 2.4 mg, every-7-days (weeks 16-20)
How to read this protocol
The chart above shows the modeled blood concentration of each compound over the 20-week duration. Each compound accumulates toward steady state (roughly 5 half-lives). The peak-to-trough ratio within each dose interval depends on the injection frequency relative to the half-life.
Use the [peak-trough estimator](/tools/peak-trough) to see predicted levels at any point, or the [clearance calculator](/tools/clearance) to estimate washout after the protocol ends. The [PCT planner](/pct-planner) estimates when to start post-cycle therapy.
Educational only. Not medical advice. Concentration values are modeled estimates based on population pharmacokinetics, not predictions of individual blood levels.