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Harm-reduction information only — not medical advice. In crisis or experiencing adverse effects, contact a healthcare professional or your local emergency services immediately.

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Pharmaceuticals/Chemicals

Progesterone (Vaginal)

Vaginal P4

Vaginal micronized progesterone; bypasses much first-pass metabolism.

🚧 Expanded guide coming soon. This compound has PK data and a source — a full overview, mechanism, and dosing guide is pending editorial review.

Pharmacokinetic summary

Model tier
Advanced (t½ + Cmax + Tmax + F)
Half-life
0.9 days
Cmax
12.3 ng/mL
Tmax
0.3 days
Bioavailability
50%
Typical dose
100–400 mg

Related compounds

Progesterone (Oral)

Micronized oral progesterone; short half-life with high first-pass metabolism.

Estradiol Topical (EstroGel)

Transdermal estradiol for feminizing HRT. Steady low-level delivery.

Estradiol Cypionate

Injectable estradiol cypionate used in feminizing HRT.

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