Masteron Enanthate
Drostanolone Enth · Mast E
Longer-acting drostanolone ester. Simple model — peak calibrated.
Key takeaways
- Long-ester drostanolone (DHT derivative); the propionate was the breast-cancer drug Drolban.
- ~8-day half-life; twice-weekly injection instead of the propionate's every-other-day schedule.
- Cannot aromatize and mildly anti-estrogenic; a hardening agent, not a mass builder.
- Androgenic sides only (hair, skin, prostate); not hepatotoxic. Ester PK is extrapolated from propionate.
Reported dosing protocols
Protocols reported in research literature and clinic/community use — informational context, not a dosing recommendation.
| Use case | Dose | Route | Frequency | Duration |
|---|---|---|---|---|
| Cutting (community) | 200–400 mg weekly | IM | 2× weekly | 8–12 weeks |
Pharmacokinetic summary
- Model tier
- Simple (t½ + F, Tmax estimated)
- Half-life
- 8 days
- Cmax
- 95.8 ng/dL
- Bioavailability
- 73%
- Typical dose
- 200–400 mg
Harm reduction
- Aromatizes
- No
- DHT derivative
- Yes
- Injection frequency
- 2×/week
Frequently asked questions
Enanthate vs propionate — why pick one?
Same hormone, different schedule. Enanthate's ~8-day half-life supports twice-weekly injection; propionate's ~2-day half-life needs every-other-day shots but clears faster if side effects appear. Weekly milligrams and effects are otherwise interchangeable.
Does Masteron block estrogen?
Partially. Drostanolone can't aromatize and weakly antagonizes estrogenic signaling, producing a mild anti-estrogenic effect. It won't manage estradiol from a heavy testosterone dose the way an aromatase inhibitor would.
Can Masteron enanthate be run alone?
Reported protocols almost always pair it with testosterone, since it suppresses the HPTA without providing any estrogenic activity. Solo use risks the low-estradiol symptoms (joints, libido, mood) that follow suppressed testosterone with no aromatization.
References
- Llewellyn Anabolics (11th ed.) — Cmax calibrated to ng/dL serum peak. Drostanolone enanthate ester data extrapolated from propionate.
- Drostanolone overview (Wikipedia, citing Llewellyn 2011) — History and pharmacology summary; the enanthate ester's PK is extrapolated from the propionate data described there.
Related compounds
Masteron Propionate
DHT-derived drostanolone propionate; anti-estrogenic, cutting agent. Simple model — peak calibrated.
Testosterone Enanthate
Long-acting testosterone ester; the most common TRT and cycle base. Reaches steady state in ~5 weeks.
Testosterone Cypionate
Standard US TRT ester with a slightly longer release tail than enanthate. Steady state ~4–5 weeks.
Protocols featuring Masteron Enanthate
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