# Trenbolone Enanthate

*Also known as: Tren E*

Long-acting 19-nor injectable; potent androgen with no aromatization. Simple model — peak calibrated.

## Overview

Trenbolone enanthate is a potent 19-nor synthetic androgen (a derivative of nandrolone, originally developed for veterinary cattle finishing) carrying a C17beta enanthate ester. Free trenbolone binds the androgen receptor with roughly three times the affinity of testosterone and does not aromatize to estradiol, nor is it 5-alpha-reduced. Its 11-day half-life supports a twice-weekly injection schedule in research protocols, with a 2-3 week run-up to steady serum levels. The lack of aromatization removes estrogenic water retention but does not remove cardiovascular strain. Trenbolone is notorious for dyslipidemia, renal stress, and psychological effects, and harm-reduction monitoring focuses on blood pressure, lipids, and kidney markers. Hepatotoxicity is rated mild, and HPTA suppression is profound and fast.

## Pharmacokinetics

- **Model tier:** simple
- **Half-life:** 11.0 days (264 hours)
- **Cmax:** 98.5 ng/dL
- **Bioavailability:** 71%

## Dosing

- **Default dose:** 200 mg
- **Typical range:** 150–400 mg
- **Units:** ng/dL

## Harm reduction

- **Aromatizes:** No
- **DHT derivative:** No
- **Hepatotoxicity:** mild
- **Injection frequency:** 2×/week
- **Interaction notes:** Trenbolone + PDE5 inhibitors (e.g. tadalafil) raises risk of cardiovascular strain and "Tren cough". Monitor closely.

## Detection time (anti-doping)

- **Window:** 30–60 days post-last-dose
- **Target metabolite:** Epitrenbolone (17α-trenbolone) glucuronide
- **Assay:** LC-MS/MS
- **Notes:** Epitrenbolone glucuronide detectable ~32 days (Sobolevsky & Rodchenkov 2015). Long-ester depot extends release but detection ceiling is ~1–2 months.

## Source

- **Label:** Trenbolone ester PK
- **URL:** https://www.sciencedirect.com/science/article/abs/pii/S002228602030452X
- **Notes:** Cmax calibrated to ng/dL serum peak.

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**Canonical URL:** https://anabolicdex.com/compounds/trenbolone-enanthate
**Plot:** https://anabolicdex.com/plot?compound=trenbolone-enanthate