# Testosterone Enanthate

*Also known as: Test E, TE, Test Enth*

Long-acting testosterone ester; the most common TRT and cycle base. Reaches steady state in ~5 weeks.

## Overview

Testosterone enanthate is a long-acting synthetic testosterone ester and the most common base compound in both clinical TRT and non-medical cycles. Once injected, tissue esterases cleave the ester and release free testosterone, which binds the androgen receptor and drives the classic androgenic-anabolic effects: protein synthesis, nitrogen retention, erythropoiesis, and HPTA feedback. Its 7.19-day half-life gives a peak around 1.4 days post-injection with roughly 5 weeks to steady state, which is why research protocols have used twice-weekly injection to smooth the peak-to-trough swing. It aromatizes readily to estradiol and 5-alpha-reduces to DHT, so the real harm-reduction work is monitoring E2, hematocrit, PSA, and lipids. HPTA suppression is complete and rapid, and recovery requires a structured PCT. It is not hepatotoxic.

## Pharmacokinetics

- **Model tier:** linear-regression
- **Half-life:** 7.2 days (172.56 hours)
- **Cmax:** 1122 ng/dL
- **Tmax:** 1.4 days
- **Bioavailability:** 72%

## Dosing

- **Default dose:** 200 mg
- **Typical range:** 100–600 mg
- **Units:** ng/dL

## Harm reduction

- **Aromatizes:** Yes
- **DHT derivative:** No
- **Injection frequency:** 2×/week
- **Bloodwork range:** 300–1000 ng/dL (Eugonadal total T)

## Detection time (anti-doping)

- **Window:** 60–90 days post-last-dose
- **Target metabolite:** Testosterone/epitestosterone ratio (T/E) + GC/C/IRMS confirmation
- **Assay:** GC-MS/MS (profile) + GC/C/IRMS
- **Notes:** Detected via altered steroid profile (T/E ratio), confirmed by carbon isotope ratio mass spectrometry. No single long-term metabolite — detection is profile-based. Window is dose- and duration-dependent.

## Source

- **Label:** JCEM / Physiological Reviews
- **URL:** https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4721027/
- **Notes:** Advanced + Linear Regression model. Cmax is sublinear in dose.

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**Canonical URL:** https://anabolicdex.com/compounds/testosterone-enanthate
**Plot:** https://anabolicdex.com/plot?compound=testosterone-enanthate