# PEG-MGF (Pegylated MGF)

*Also known as: PEG-MGF*

Pegylated mechano growth factor with extended half-life versus native MGF; used for recovery research.

## Overview

PEG-MGF is a PEGylated form of mechano growth factor, the IGF-1Ec splice variant that muscle produces after mechanical overload. Attaching a polyethylene glycol chain shields the peptide from rapid enzymatic breakdown, extending its half-life from roughly 30 minutes to around 19 hours and improving subcutaneous bioavailability to near 60%. Like native MGF, it targets satellite-cell activation and local repair signaling, but the longer residence time allows less frequent dosing than the parent compound. Human pharmacokinetic data is thin, and PEG-MGF is not an approved medication. Most supporting evidence comes from rodent muscle-injury models and in vitro satellite-cell studies, with the PEGylation pharmacology borrowed from better-characterized PEGylated drugs.

## Pharmacokinetics

- **Model tier:** simple
- **Half-life:** 0.8 days (19.200000000000003 hours)
- **Bioavailability:** 60%

## Dosing

- **Default dose:** 0.4 mg
- **Typical range:** 0.2–0.8 mg
- **Units:** ng/mL

## Source

- **Label:** Estimated
- **Notes:** PEGylation extends the short MGF half-life considerably.

**Tags:** muscle-building, recovery-healing

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**Canonical URL:** https://anabolicdex.com/compounds/peg-mgf
**Plot:** https://anabolicdex.com/plot?compound=peg-mgf