# MOTS-c

*Also known as: Mitochondrial-derived peptide*

Mitochondrial-derived peptide that regulates metabolic homeostasis and AMPK signaling.

## Overview

MOTS-c is a mitochondrial-derived peptide encoded by a short open reading frame in mitochondrial DNA, specifically within the 16S rRNA gene. It acts as a signaling molecule that regulates metabolic homeostasis, including AMPK activation, improved insulin sensitivity, and the upregulation of antioxidant defenses. It is studied as an exercise mimetic and metabolic regulator. MOTS-c has an estimated half-life of about 12 hours and around 50% bioavailability. Most of the supporting evidence comes from cell and animal work, with human pharmacokinetic data very limited. A few small human studies have begun, but MOTS-c is not an approved medication, and the dosing comes from preclinical extrapolation.

## Pharmacokinetics

- **Model tier:** simple
- **Half-life:** 0.5 days (12 hours)
- **Bioavailability:** 50%

## Dosing

- **Default dose:** 5 mg
- **Typical range:** 2.5–10 mg
- **Units:** ng/mL

## Source

- **Label:** Estimated (preclinical)
- **Notes:** Mitochondrial-derived peptide; AMPK activation, human PK limited.

**Tags:** metabolic, weight-loss

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**Canonical URL:** https://anabolicdex.com/compounds/mots-c
**Plot:** https://anabolicdex.com/plot?compound=mots-c