# MGF (Mechano Growth Factor)

*Also known as: MGF, IGF-1Ec*

IGF-1 splice variant produced in response to mechanical load; involved in muscle repair signaling.

## Overview

Mechano growth factor (MGF) is a splice variant of IGF-1, specifically the IGF-1Ec isoform, that skeletal muscle produces in response to mechanical load and damage. Unlike the systemic IGF-1Ea variant, MGF acts locally, activating satellite cells and triggering muscle repair signaling within hours of injury. Its distinct C-terminal E-domain drives these regenerative effects and separates it from other IGF-1 splice forms. The peptide clears fast, with an estimated half-life of roughly 30 minutes and around 50% subcutaneous bioavailability. Research contexts typically reference 200 to 800 mcg doses, but these numbers come from preclinical work rather than controlled human trials. Human pharmacokinetic data is essentially absent, and MGF is not an approved medication. Because native MGF degrades in minutes, researchers often turn to PEG-MGF for a longer-acting alternative.

## Pharmacokinetics

- **Model tier:** simple
- **Half-life:** 0.0 days (0.48 hours)
- **Bioavailability:** 50%

## Dosing

- **Default dose:** 0.4 mg
- **Typical range:** 0.2–0.8 mg
- **Units:** ng/mL

## Detection time (anti-doping)

- **Window:** 2–5 days post-last-dose
- **Target metabolite:** IGF-1Ec (MGF) C-terminal E-domain peptide
- **Assay:** LC-MS
- **Notes:** WADA prohibits growth factors including MGF under S2.3, detected in urine by LC-MS. The E-domain peptide distinguishes MGF from other IGF-1 splice variants.

## Source

- **Label:** Estimated
- **Notes:** Very short half-life (minutes); splice variant of IGF-1. Yang & Goldspink 2002.

**Tags:** muscle-building, recovery-healing

---

**Canonical URL:** https://anabolicdex.com/compounds/mgf
**Plot:** https://anabolicdex.com/plot?compound=mgf