# Mesterolone (Proviron)

*Also known as: Proviron*

Oral DHT derivative; low bioavailability, used for SHBG binding / anti-estrogenic effect.

## Overview

Mesterolone (brand Proviron) is an oral anabolic-androgenic steroid and a direct DHT derivative. Unlike most oral AAS it is not 17-alpha-alkylated, instead carrying a 1-methyl group, so its hepatotoxicity is rated mild rather than severe. Mesterolone binds the androgen receptor, but its distinctive role comes from high affinity for sex hormone-binding globulin (SHBG), which frees up circulating testosterone and produces a net anti-estrogenic effect rather than mass gain. The dataset records a half-life of about 12.5 hours, Cmax near 400 ng/dL, and notably low bioavailability of only 3% (Bayer prescribing information), reflecting heavy first-pass loss. Because it does not aromatize and antagonizes estrogenic action, it is used to manage SHBG and estrogen-related side effects, not as a primary anabolic.

## Pharmacokinetics

- **Model tier:** advanced
- **Half-life:** 0.5 days (12.4999999992 hours)
- **Cmax:** 400 ng/dL
- **Tmax:** 0.1 days
- **Bioavailability:** 3%

## Dosing

- **Default dose:** 50 mg
- **Typical range:** 25–100 mg
- **Units:** ng/dL

## Harm reduction

- **Aromatizes:** No
- **DHT derivative:** Yes
- **Hepatotoxicity:** mild
- **Injection frequency:** Oral, daily

## Source

- **Label:** Bayer Proviron PI
- **URL:** https://resources.bayer.com.au/resources/uploads/PI/file9420.pdf

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**Plot:** https://anabolicdex.com/plot?compound=mesterolone-proviron