# Estradiol Topical (EstroGel)

*Also known as: EstroGel, E2 Gel*

Transdermal estradiol for feminizing HRT. Steady low-level delivery.

## Overview

Topical estradiol (EstroGel) is a transdermal estradiol preparation used in feminizing hormone therapy and for menopausal hormone replacement. The alcohol-based gel carries 17-beta-estradiol across the skin into systemic circulation, producing steady low-level delivery that bypasses the first-pass metabolism of oral estradiol and avoids the elevated estrone and clotting-factor changes associated with the oral route. The compound has an apparent roughly 36-hour half-life reflecting the skin reservoir, peaks within roughly 4 hours, and shows about 62% bioavailability, supporting once-daily application. Effects include stable physiological estradiol levels with a metabolically favorable profile, while the dominant practical concern is secondary transfer to others via skin or clothing contact before the gel has dried fully. Harm reduction centers on covering the application site, washing hands, allowing the gel to dry before dressing or contact, and rotating application sites to avoid local skin irritation.

## Pharmacokinetics

- **Model tier:** advanced
- **Half-life:** 1.5 days (36 hours)
- **Cmax:** 2.16558 pg/mL
- **Tmax:** 0.2 days
- **Bioavailability:** 62%

## Dosing

- **Default dose:** 1 mg
- **Typical range:** 0.5–1.5 mg
- **Units:** pg/mL

## Source

- **Label:** PubMed / EstroGel label
- **URL:** https://pubmed.ncbi.nlm.nih.gov/9389778/

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**Canonical URL:** https://anabolicdex.com/compounds/estradiol-topical
**Plot:** https://anabolicdex.com/plot?compound=estradiol-topical