# DNP

*Also known as: 2,4-Dinitrophenol*

Industrial mitochondrial uncoupler; extremely hazardous with documented fatalities. For harm-reduction reference only.

## Overview

DNP (2,4-dinitrophenol) is an industrial mitochondrial uncoupling agent that was briefly prescribed for weight loss in the 1930s before being abandoned after documented fatalities, and it remains one of the most hazardous compounds encountered in self-directed use. It carries protons across the mitochondrial inner membrane, bypassing ATP synthase, so energy from nutrient oxidation is released as heat rather than stored, raising metabolic rate and body temperature in direct proportion to dose. The compound has a very long roughly 89-hour half-life, so accumulation across consecutive doses is rapid and a small increase compounds over days, and there is no antidote once toxicity begins. Effects include rapid weight loss through thermogenesis, while the documented and frequent risks are hyperthermia, tachycardia, dehydration, cataracts, agranulocytosis, and death, with a narrow margin between a perceived working dose and a fatal one. This entry exists for harm reduction only: DNP has no safe recreational dose and should not be used.

## Pharmacokinetics

- **Model tier:** advanced
- **Half-life:** 3.7 days (88.77984000000001 hours)
- **Cmax:** 0.04166666667 mcg/mL
- **Tmax:** 0.0 days
- **Bioavailability:** 100%

## Dosing

- **Default dose:** 100 mg
- **Typical range:** 50–200 mg
- **Units:** mcg/mL

## Harm reduction

- **Aromatizes:** No
- **Hepatotoxicity:** severe
- **Interaction notes:** DNP is exceptionally dangerous — narrow therapeutic window, documented fatalities. This entry is for harm reduction only.

## Source

- **Label:** PMC DNP PK
- **URL:** https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6468406/
- **Notes:** Estimates from Fig. 4. No good bioavailability source.

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**Canonical URL:** https://anabolicdex.com/compounds/dnp
**Plot:** https://anabolicdex.com/plot?compound=dnp