# CJC-1295 without DAC (Modified GRF 1-29)

*Also known as: Mod GRF 1-29, CJC-1295 NO DAC, CJC no DAC*

Short-acting GHRH analog (~30 min half-life) usually paired with a GHRP for pulsatile GH release.

## Overview

CJC-1295 without DAC, also called modified GRF 1-29, is a short-acting synthetic analog of growth hormone-releasing hormone (GHRH). It is engineered with four amino acid substitutions that resist enzymatic degradation, and it works at GHRH receptors on the pituitary to stimulate growth hormone release in a pulsatile, physiologic pattern. Without the drug affinity complex (DAC) found in the longer-acting version, its half-life drops to roughly 30 minutes with around 60% subcutaneous bioavailability. That short residence time is why it is typically paired with a GHRP like ipamorelin or GHRP-2, since the two classes amplify GH release through different pathways. CJC-1295 without DAC reached early clinical study but is not an approved medication.

## Pharmacokinetics

- **Model tier:** simple
- **Half-life:** 0.0 days (0.48 hours)
- **Bioavailability:** 60%

## Dosing

- **Default dose:** 0.3 mg
- **Typical range:** 0.1–0.5 mg
- **Units:** ng/mL

## Source

- **Label:** Estimated
- **Notes:** Without DAC the half-life is ~30 minutes; typically combined with a GHRP.

**Tags:** muscle-building, anti-aging-longevity

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**Canonical URL:** https://anabolicdex.com/compounds/cjc-1295-no-dac
**Plot:** https://anabolicdex.com/plot?compound=cjc-1295-no-dac