# Anavar

*Also known as: Oxandrolone, Var*

Mild oral oxandrolone; favored in cutting and female use due to low androgenicity.

## Overview

Anavar (oxandrolone) is an oral 17-alpha-alkylated DHT derivative, originally reintroduced clinically for weight gain after trauma, burns, and chronic infection. An added oxygen atom at the A-ring gives it a high anabolic-to-androgenic ratio and one of the mildest side-effect profiles in the oral AAS group, which is why research protocols have favored it in cutting contexts and in female use. It binds the androgen receptor and does not aromatize and is not 5-alpha-reduced (already a DHT derivative). Its 9.5-hour half-life supports twice-daily oral dosing. Hepatotoxicity is rated mild relative to other 17-alpha-alkylated orals, though liver enzyme monitoring still applies, and lipids (notably HDL suppression) are the main harm-reduction target. HPTA suppression occurs but is dose- and duration-dependent.

## Pharmacokinetics

- **Model tier:** advanced
- **Half-life:** 0.4 days (9.504000000000001 hours)
- **Cmax:** 772 ng/dL
- **Tmax:** 0.1 days
- **Bioavailability:** 63%

## Dosing

- **Default dose:** 20 mg
- **Typical range:** 10–50 mg
- **Units:** ng/dL

## Harm reduction

- **Aromatizes:** No
- **DHT derivative:** Yes
- **Hepatotoxicity:** mild
- **Injection frequency:** Oral, 2×/day

## Detection time (anti-doping)

- **Window:** 21–28 days post-last-dose
- **Target metabolite:** 17β-hydroxymethyl-17α-methyl-18-nor-2-oxa-5α-androsta-13-en-3-one
- **Assay:** LC-MS/MS
- **Notes:** Long-term metabolite detectable up to 18 days (Guddat 2013). Parent oxandrolone clears within hours–days.

## Source

- **Label:** PMC oxandrolone PK
- **URL:** https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7134583/

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**Canonical URL:** https://anabolicdex.com/compounds/anavar
**Plot:** https://anabolicdex.com/plot?compound=anavar